2. Metabolic Disease

Metabolic Disease

Metabolic Disease

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Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-114635
    Dexecadotril 112573-72-5 98%
    Dexecadotril (Retorphan) is a powerful and selective neprilysin (NEP) inhibitor. Dexecadotril is a prodrug of the R-enantiomers of Thiorphan (HY-W013375). Dexecadotril shows intestinal antisecretatory action.
    Dexecadotril
  • HY-114695
    Prostaglandin F2α-1-glyceryl ester 43042-79-1 98%
    Prostaglandin F2α-1-glyceryl ester can be oxidized by 15-hydroxyprostaglandin dehydrogenase (15-HPGDH).
    Prostaglandin F2α-1-glyceryl ester
  • HY-114700
    ZINC08438472 443872-20-6 98%
    ZINC08438472 is a potent and selective peroxisome proliferator activated receptors-α (PPAR-α) agonist with an EC50 value of 12.1 nM. ZINC08438472 is promising for research of diabetes, hyperlipidaemia and inflammatory disorders.
    ZINC08438472
  • HY-114754
    BemPPOX 1998101-23-7 98%
    BemPPOX is an orally active, potent dog gastric lipase (DGL) inhibitor with Xl50 (the inhibitor molar excess leading to 50% lipase inhibition) of 0.5. BemPPOX is also a good inhibitor of GPLRP2 (xl50=0.64). BemPPOX efficiently regulates the gastrointestinal lipolysis and slows down the overall lipolysis process in rats. BemPPOX has the potential for obesity research.
    BemPPOX
  • HY-114853
    BVT.13 756813-87-3 98%
    BVT.13 is an orally active and selective PPARγ agonist with a maximal efficacy similar to that of Rosiglitazone (HY-17386). In addition, BVT.13 exhibits antidiabetic activity in ob/ob mice.
    BVT.13
  • HY-115014
    Cibenzoline succinate 100678-32-8 98%
    Cibenzoline succinate (Cifenline succinate) is the succinate form of Cibenzoline (HY-106577). Cibenzoline succinate is an inhibitor for ATP-sensitive potassium (KATP) channel by affecting the pore-forming Kir6.2 subunit with IC50 of 22.2 µM. Cibenzoline succinate affects insulin secretion and exhibits antiarrhythmic and antidiabetic activities.
    Cibenzoline succinate
  • HY-115358
    Lignoceroyl Ethanolamide 10015-68-6 98%
    Lignoceroyl ethanolamide is a member of the family of fatty N-acyl ethanolamines collectively called endocannabinoids. Whereas lignoceric acid has been detected at relatively high levels in rat cerebrospinal fluid, the specific role and relative importance of its ethanolamine metabolite have not been determined.
    Lignoceroyl Ethanolamide
  • HY-115410
    NG-Amino-L-arginine hydrochloride 1031799-40-2 98%
    NG-Amino-L-arginine hydrochloride induces inactivation of the citrulline-forming activity of the nNOS, iNOS, and eNOS isoforms with Ki values of 0.3 μM, 3 μM, and 2.5 μM, respectively.
    NG-Amino-L-arginine hydrochloride
  • HY-115708
    C22 Phytoceramide (t18:0/22:0) 164576-03-8 98%
    C22 Phytoceramide is a sphingolipid that has been found in Moro blood orange (C. sinensis) peels. It has also been found in primary human astrocytes.
    C22 Phytoceramide (t18:0/22:0)
  • HY-115731
    Tocol 119-98-2 98%
    (±)-Tocol is a synthetic vitamin E derivative.nlike (±)-α-tocopherol, (±)-tocol does not suppress retinol-induced erythrocyte hemolysis or increase microviscosity of rat liver phosphatidylcholine (PC) liposomes.
    Tocol
  • HY-115773
    NMTCA 103659-08-1 98%
    NMTCA (NMTPRO) is a sulfur-containing N-nitrosamino acid. NMTCA can be used as an indicator of endogenous nitrosation by gas chromatography-thermalenergyanalysis.
    NMTCA
  • HY-116017
    C10 Ceramide 111122-57-7 98%
    C10 Ceramide is an ester product.
    C10 Ceramide
  • HY-116143
    MAGL-IN-12 1352011-38-1 98%
    SAR127303 is an orally active, selective, competitive monoacylglycerol lipase (MAGL) covalent inhibitor with IC50s of 3.8 nM and 29 nM for mouse and human MAGL, respectively. SAR127303 potently elevates hippocampal levels of 2-AG in mice. SAR127303 decreased long term potentiation (LTP) of CA1 synaptic transmission and acetylcholine release in the hippocampus. SAR127303 produces antinociceptive effects in assays of inflammatory and visceral pain. SAR127303 slows down epileptogenesis.
    MAGL-IN-12
  • HY-116166
    Methyl 3-hydroxyundecanoate 129758-71-0 98%
    Methyl 3-hydroxyundecanoate (3-Hydroxy undecanoic acid methyl ester) is an ester product.
    Methyl 3-hydroxyundecanoate
  • HY-116259
    PT-S58 1356497-92-1 98%
    PT-S58, a GSK0660 derivative, is a PPARβ/δ full antagonist with an IC50 value of 98 nM. PT-S58 inhibits the agonist-induced transcriptional activity of PPARβ/δ in vitro.
    PT-S58
  • HY-116422
    N,N-Dimethyl sphinganine 17267-46-8 98%
    N,N-Dimethyl sphinganine is an ester product.
    N,N-Dimethyl sphinganine
  • HY-116503
    Methyl 3-hydroxytridecanoate 150024-70-7 98%
    Methyl 3-hydroxytridecanoate (3-Hydroxy tridecanoic acid methyl ester) is an ester product.
    Methyl 3-hydroxytridecanoate
  • HY-116508
    MK 319 1462383-00-1 98%
    MK 319 is a selective aldose reductase (AR) inhibitor with an IC50 of 0.3 μM. MK 319 can be utilized in diabetes research.
    MK 319
  • HY-116576
    LY219057 150351-93-2 98%
    LY219057 is a potent antagonist of cholecystokinin octapeptide (CCK-8), with the ID50 of 287.5 nM.
    LY219057
  • HY-116600
    AL-4114 139911-05-0 98%
    AL-4114 is an aldose reductase inhibitor which can be utilized in research related to the prevention of diabetic cataractogenesis.
    AL-4114
Cat. No. Product Name / Synonyms Application Reactivity